{"id":8306,"date":"2026-05-08T22:20:21","date_gmt":"2026-05-08T22:20:21","guid":{"rendered":"https:\/\/trusthillpharmacy.de\/?post_type=product&#038;p=8306"},"modified":"2026-05-11T23:21:55","modified_gmt":"2026-05-11T23:21:55","slug":"oxycontin-40-mg","status":"publish","type":"product","link":"https:\/\/trusthillpharmacy.de\/de\/shop\/oxycontin-40-mg\/","title":{"rendered":"Oxycontin 40 mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Oxycontin<\/a> 40 mg<\/h1>\n<div class=\"flex-grow custom-scrollbar blackbox-chat-area hide-scrollbar\">\n<div class=\"relative h-full left-0\">\n<div class=\"relative sm:px-4 pb-[80px] md:pb-[20px] mx-auto\">\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"fxTQE5p1RKBxcyconlDBa\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<div class=\"flex-grow custom-scrollbar blackbox-chat-area hide-scrollbar\">\n<div class=\"relative h-full left-0\">\n<div class=\"relative sm:px-4 pb-[80px] md:pb-[20px] mx-auto\">\n<div>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"AukxbbOk55xP59GbLuk7C\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0 streaming\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharmacy.de\/de\/\">Oxycodon bereits<\/a> 40 mg ist eine Markenformulierung mit verl\u00e4ngerter Wirkstofffreisetzung von <strong>Oxycodonhydrochlorid<\/strong>Oxycodon ist ein starkes Opioid-Analgetikum. Die St\u00e4rke 40 mg bezieht sich auf Tabletten, die 40 Milligramm Oxycodon pro Dosis enthalten und f\u00fcr folgende Zwecke bestimmt sind:\u00a0<strong>einmal alle 12 Stunden<\/strong>\u00a0Die Verabreichung erfolgt bei opioidtoleranten Patienten zur Behandlung m\u00e4\u00dfiger bis starker chronischer Schmerzen (z. B. Tumorschmerzen oder postoperative Schmerzen).\u00a0<strong>nicht<\/strong>\u00a0Bei akuten Schmerzen oder bei opioidnaiven Patienten aufgrund des hohen \u00dcberdosierungsrisikos.<\/p>\n<h4>Wichtigste Fakten und Beweise<\/h4>\n<ul>\n<li><strong>Pharmakologie<\/strong>Oxycodon ist ein halbsynthetischer Opioidagonist, der an \u00b5-Opioidrezeptoren im Gehirn und R\u00fcckenmark bindet und Schmerzsignale hemmt. Die Retardformulierung nutzt eine Polymermatrix f\u00fcr eine langsame Freisetzung und sorgt so f\u00fcr einen gleichm\u00e4\u00dfigen Blutspiegel (maximale Konzentration nach 3\u20134 Stunden, Halbwertszeit ca. 4,5 Stunden). Quelle: FDA-Verschreibungsinformationen (Purdue Pharma, aktualisiert 2023).<\/li>\n<li><strong>Aussehen<\/strong>Wei\u00dfe, runde, film\u00fcberzogene Tabletten mit dem Aufdruck \u201eOP 40\u201c (seit 2010 neu formulierte, missbrauchsresistente Version, die sich zu einem Gel zerdr\u00fccken l\u00e4sst und so das Missbrauchspotenzial verringert). Nachweis: Best\u00e4tigt durch Produktspezifikationen von Purdue Pharma und DEA-Dokumente zur Einstufung von Bet\u00e4ubungsmitteln.<\/li>\n<li><strong>Dosierungsrichtlinien<\/strong>\u00a0(f\u00fcr Erwachsene, opioidtolerant):<\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Patiententyp<\/th>\n<th>Anfangsdosis<\/th>\n<th>Titration<\/th>\n<th>Max. t\u00e4glich<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Opioid-naiv<\/td>\n<td>Nicht empfohlen (verwenden Sie Oxycodon mit sofortiger Wirkstofffreisetzung).<\/td>\n<td>N \/ A<\/td>\n<td>N \/ A<\/td>\n<\/tr>\n<tr>\n<td>Opioidtolerant<\/td>\n<td>10-40 mg alle 12 Stunden<\/td>\n<td>Steigerung um 25-50% alle 1-2 Tage<\/td>\n<td>360 mg (\u00fcberwacht)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0 streaming\">\n<ul>\n<li>Umrechnung: 40 mg OxyContin entsprechen etwa 60 mg oralem Morphin\u00e4quivalent pro Tag. Zur genauen Dosierung verwenden Sie bitte die \u00e4quianalgetischen Tabellen der FDA.<\/li>\n<li><strong>Bioverf\u00fcgbarkeit<\/strong>: ~60\u201387 % orale Aufnahme; Nahrung erh\u00f6ht die Absorption leicht. CYP3A4\/2D6-Metabolismus; genetisch bedingte langsame Metabolisierer haben ein h\u00f6heres \u00dcberdosierungsrisiko (Studien in ).\u00a0<em>Klinische Pharmakologie Therapie<\/em>, 2015).<\/li>\n<\/ul>\n<h4>Klinische Anwendung und Wirksamkeit<\/h4>\n<ul>\n<li><strong>Indikationen<\/strong>Anhaltende Schmerzen, die eine kontinuierliche Opioidtherapie erfordern (z. B. Schmerzskala \u2265 5\/10). RCTs (z. B.\u00a0<em>Schmerz<\/em>\u00a0Journal, 2004) zeigen eine \u00fcberlegene Schmerzkontrolle gegen\u00fcber Placebo \u00fcber 12 Wochen bei chronischen R\u00fcckenschmerzen.<\/li>\n<li><strong>Wirksamkeitsdaten<\/strong>In Studien reduzierte die Einnahme von 40 mg alle 12 Stunden die Schmerzen bei 60 % der Patienten um 30\u201350 % im Vergleich zu 20 % unter Placebo (Cochrane-Review, 2017). Langfristig entwickelt sich bei 20\u201330 % der Patienten innerhalb weniger Monate eine Toleranz.<\/li>\n<\/ul>\n<h4>Risiken und Nebenwirkungen<\/h4>\n<p class=\"mb-2 last:mb-0\">Hohes Missbrauchspotenzial (Bet\u00e4ubungsmittel der Anlage II). Fakten belegt durch Daten der CDC und der NIH:<\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>H\u00e4ufig (\u226510 %)<\/th>\n<th>Schwerwiegend (1-5%)<\/th>\n<th>Anzeichen einer \u00dcberdosis<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Verstopfung, \u00dcbelkeit, Schl\u00e4frigkeit, Juckreiz<\/td>\n<td>Atemdepression, Hypotonie, Krampfanf\u00e4lle<\/td>\n<td>Pinpoint pupils, slow breathing (&lt;12\/min), coma; lethal dose ~200mg in naive users (NIDA stats)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0 streaming\">\n<ul>\n<li><strong>Sucht\/\u00dcberdosis<\/strong>Laut Daten der CDC aus dem Jahr 2019 steht Oxycodon mit verl\u00e4ngerter Wirkstofffreisetzung in Zusammenhang mit 15 % der Opioid-Todesf\u00e4lle in den USA. Naloxon hebt eine \u00dcberdosierung auf (FDA-zugelassen).<\/li>\n<li><strong>Kontraindikationen<\/strong>Akutes Asthma, paralytischer Ileus, k\u00fcrzliche Einnahme von MAO-Hemmern. Vermeiden Sie die gleichzeitige Einnahme von Alkohol oder Benzodiazepinen (das Risiko eines Atemstillstands verdreifacht sich).\u00a0<em>JAMA<\/em>\u00a02017).<\/li>\n<li><strong>Widerrufsrecht<\/strong>Die Symptome erreichen ihren H\u00f6hepunkt 72 Stunden nach der letzten Dosis (Schwei\u00dfausbr\u00fcche, Angstzust\u00e4nde); die Dosis sollte w\u00f6chentlich um 10-25 % reduziert werden.<\/li>\n<\/ul>\n<h4>Missbrauch und Stra\u00dfenkontext<\/h4>\n<ul>\n<li><strong>Stra\u00dfenwert<\/strong>: 1-2 US-Dollar pro 40-mg-Pille (DEA-Sch\u00e4tzungen 2023), oft zerkleinert\/geschnupft trotz Missbrauchsverhinderungstechnologie (Erfolgsrate sank nach 2010 um 80 %)\u00a0<em>NEJM<\/em>\u00a02012).<\/li>\n<li><strong>Detektion<\/strong>Urintests sind 1-4 Tage, Bluttests 24 Stunden positiv. Mit Fentanyl versetzte F\u00e4lschungen sind weit verbreitet (DEA-Warnungen).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Warnungen<\/strong>Nur auf \u00e4rztliche Verschreibung verwenden. Missbrauch verursacht in den USA j\u00e4hrlich \u00fcber 50.000 Todesf\u00e4lle (CDC 2022). Konsultieren Sie einen Arzt f\u00fcr eine individuelle Beratung; dies sind Fakten von FDA\/DEA\/NIH, keine medizinische Beratung. Hilfe beim Entzug erhalten Sie unter der SAMHSA-Hotline: 1-800-662-HELP.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex items-center justify-end gap-1 transition-opacity duration-100 opacity-0 group-hover:opacity-100 group-focus-within:opacity-100 md:absolute md:-right-10 md:-top-2\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Oxycontin 40mg OxyContin 40mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 40mg strength refers to tablets containing 40 milligrams of oxycodone per dose, designed for\u00a0once every 12 hours\u00a0administration in opioid-tolerant patients for management of moderate to severe chronic pain (e.g., cancer pain or post-surgical). It&#8217;s\u00a0not\u00a0for acute pain or opioid-naive &hellip; <a href=\"https:\/\/trusthillpharmacy.de\/de\/shop\/oxycontin-40-mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Oxycontin 40 mg<\/span><\/a><\/p>","protected":false},"featured_media":8308,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[262],"class_list":["post-8306","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-oxycontin-40mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxycontin 40mg - Trusthill Pharmacy<\/title>\n<meta name=\"description\" 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