{"id":8313,"date":"2026-05-08T22:24:46","date_gmt":"2026-05-08T22:24:46","guid":{"rendered":"https:\/\/trusthillpharmacy.de\/?post_type=product&#038;p=8313"},"modified":"2026-05-29T21:53:22","modified_gmt":"2026-05-29T21:53:22","slug":"oxycontin-80-mg","status":"publish","type":"product","link":"https:\/\/trusthillpharmacy.de\/de\/shop\/oxycontin-80-mg\/","title":{"rendered":"Oxycontin 80 mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Oxycontin<\/a> 80 mg<\/h1>\n<div>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"b3-qqov2ScRehgun9NPjO\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharmacy.de\/de\/\">Oxycodon bereits<\/a> 80 mg ist eine Markenformulierung mit verl\u00e4ngerter Wirkstofffreisetzung von <strong>Oxycodonhydrochlorid<\/strong>, ein starkes Opioid-Analgetikum. Die St\u00e4rke von 80 mg geh\u00f6rt zu den h\u00f6heren Dosen und wird typischerweise zur Behandlung schwerer, chronischer Schmerzen (z. B. Tumorschmerzen oder postoperative Schmerzen) bei opioidtoleranten Patienten verschrieben. Es ist f\u00fcr\u00a0<strong>12-Stunden-Dosierung<\/strong>\u00a0zur kontinuierlichen Schmerzlinderung, nicht zur sofortigen Schmerzlinderung wie bei Durchbruchschmerzen.<\/p>\n<h4>Wichtigste Fakten und Beweise<\/h4>\n<ul>\n<li><strong>Pharmakologie<\/strong>Oxycodon ist ein halbsynthetischer Opioidagonist, der an \u00b5-Opioidrezeptoren im Gehirn und R\u00fcckenmark bindet und die Schmerzwahrnehmung ver\u00e4ndert. Die Retardformulierung (seit 2010 missbrauchssichere Formulierung) verwendet eine Polymermatrix, um die Aufl\u00f6sung zu verlangsamen und so das Risiko des Zerkleinerns oder Schnupfens zu verringern. Maximale Plasmaspiegel werden etwa 3 Stunden nach der Einnahme erreicht; die Halbwertszeit betr\u00e4gt 4,5 Stunden (Quelle: FDA-Verschreibungsinformationen, Purdue Pharma).<\/li>\n<li><strong>Dosierungsrichtlinien<\/strong>\u00a0(von der FDA zugelassenen Kennzeichnung):<\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Patiententyp<\/th>\n<th>Anfangsdosis<\/th>\n<th>Titration<\/th>\n<th>Max. t\u00e4glich<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Opioid-naiv<\/td>\n<td>Nicht empfohlen (verwenden Sie niedrigere Dosierungen wie 10-20 mg).<\/td>\n<td>Alle 1-2 Tage um 25-50 % erh\u00f6hen.<\/td>\n<td>80 mg (aufgeteilt auf 2 x t\u00e4glich)<\/td>\n<\/tr>\n<tr>\n<td>Opioidtolerant<\/td>\n<td>40-80 mg alle 12 Stunden<\/td>\n<td>Anpassung je nach Schmerz\/Reaktion<\/td>\n<td>Kein striktes Maximum; genaue \u00dcberwachung erforderlich.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<ul>\n<li><strong>80 mg Details<\/strong>: Green-colored, round tablet (OP 80 imprint). Equivalent to ~120mg oral morphine daily when dosed BID. Not for children under 11 or &lt;50kg.<\/li>\n<li><strong>Klinische Wirksamkeit<\/strong>Studien (z. B. die NEJM-Studie von 2003) zeigen, dass es bei toleranten Patienten die Werte f\u00fcr chronische Schmerzen im Vergleich zu Placebo um 30-50 % senkt, aber es entwickelt sich schnell eine Toleranz (innerhalb von Wochen).<\/li>\n<\/ul>\n<h4>Risiken und Nebenwirkungen<\/h4>\n<p class=\"mb-2 last:mb-0\">Hochdosierte Dosen wie 80 mg tragen\u00a0<strong>erhebliche Risiken<\/strong>untermauert durch Daten der CDC und Warnhinweise der FDA:<\/p>\n<ul>\n<li><strong>\u00dcberdosis<\/strong>Die Haupttodesursache ist die Atemdepression. Die letale Dosis liegt bei unerfahrenen Anwendern bei etwa 200 mg (siehe \u00c4quivalenzrechner wie den der CDC). Naloxon hebt die Wirkung auf.<\/li>\n<li><strong>H\u00e4ufige Nebenwirkungen<\/strong>\u00a0(Inzidenz &gt;10%): Verstopfung (40-60%), \u00dcbelkeit (23%), Schl\u00e4frigkeit (23%), Juckreiz (15%).<\/li>\n<li><strong>Ernsthafte Risiken<\/strong>:<\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Risiko<\/th>\n<th>Inzidenz\/Evidenz<\/th>\n<th>Minderung<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Sucht\/Abh\u00e4ngigkeit<\/td>\n<td>8-12 % bei chronischen Konsumenten (JAMA 2014 Metaanalyse)<\/td>\n<td>Screening mit Opioid-Risikobewertungsinstrument; langsames Ausschleichen<\/td>\n<\/tr>\n<tr>\n<td>Atemversagen<\/td>\n<td>1-2 % Krankenhausaufenthalte (pro 10.000 Rezepte, FDA)<\/td>\n<td>SpO2 \u00fcberwachen; Alkohol\/Benzos vermeiden<\/td>\n<\/tr>\n<tr>\n<td>Hyperalgesie<\/td>\n<td>Paradoxe Schmerzzunahme (Tier-\/Humanstudien, Pain 2017)<\/td>\n<td>Bei Verdacht auf Opioide die Medikation rotieren.<\/td>\n<\/tr>\n<tr>\n<td>Neonatale Abstinenz (Schwangerschaft)<\/td>\n<td>Kategorie C; wenn m\u00f6glich vermeiden<\/td>\n<td>Niedrigste wirksame Dosis verwenden<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<ul>\n<li><strong>Missbrauchspotenzial<\/strong>Die vor 2010 verwendeten Versionen wurden f\u00fcr einen schnellen Rausch zerkleinert (z. B. \u201eOxy 80s\u201c, Stra\u00dfenpreis 40\u201380 $ pro Pille, laut DEA-Berichten). Die neu formulierte Version geliert beim Zerkleinern, intraven\u00f6ser Missbrauch kommt aber weiterhin vor.<\/li>\n<\/ul>\n<h4>Hinweise zu Regulierung und R\u00fccknahme<\/h4>\n<ul>\n<li><strong>Kontrollierte Substanz<\/strong>Anlage II (hohes Missbrauchspotenzial, DEA). Verschreibungspflichtig; Wiederholungsrezepte nur mit \u00e4rztlicher Genehmigung erh\u00e4ltlich.<\/li>\n<li><strong>Widerrufsrecht<\/strong>Ein abrupter Abbruch verursacht grippe\u00e4hnliche Symptome (Angstzust\u00e4nde, Schwei\u00dfausbr\u00fcche, Durchfall), die nach 72 Stunden ihren H\u00f6hepunkt erreichen. Die Dosis sollte w\u00f6chentlich um 10-25 % reduziert werden (ASAM-Richtlinien).<\/li>\n<li><strong>Wechselwirkungen<\/strong>: Die Wirkung wird durch CYP3A4-Inhibitoren (z. B. Ketoconazol) verst\u00e4rkt; gleichzeitige Anwendung mit MAO-Hemmern vermeiden.<\/li>\n<\/ul>\n<h4>Aktueller Kontext<\/h4>\n<p class=\"mb-2 last:mb-0\">Die nach 2010 erfolgte Rezeptur\u00e4nderung reduzierte die Missbrauchsraten um 75 % (JAMA 2017), trug aber zur Opioidkrise bei (z. B. Purdues Vergleich in H\u00f6he von 8 Milliarden US-Dollar, 2020). Alternativen: Fentanylpflaster, Buprenorphin zur Erhaltungstherapie.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Haftungsausschluss<\/strong>Dies sind Fakteninformationen der FDA, CDC und aus Fachzeitschriften (z. B. PubMed). Sie stellen keine medizinische Beratung dar \u2013 konsultieren Sie einen Arzt. Missbrauch kann t\u00f6dlich sein. Bei Bedarf k\u00f6nnen Sie sich an Hilfsangebote wie die SAMHSA-Helpline (1-800-662-HELP) wenden.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\"><\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Oxycontin 80mg OxyContin 80mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 80mg strength is one of the higher doses, typically prescribed for severe, chronic pain management (e.g., cancer pain or post-surgical recovery) in opioid-tolerant patients. It&#8217;s designed for\u00a012-hour dosing\u00a0to provide steady pain relief, not for immediate-release use like breakthrough &hellip; <a href=\"https:\/\/trusthillpharmacy.de\/de\/shop\/oxycontin-80-mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Oxycontin 80 mg<\/span><\/a><\/p>","protected":false},"featured_media":8319,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[263],"class_list":["post-8313","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-oxycontin-80mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ 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