{"id":7950,"date":"2026-04-21T12:42:00","date_gmt":"2026-04-21T12:42:00","guid":{"rendered":"https:\/\/trusthillpharmacy.de\/?post_type=product&#038;p=7950"},"modified":"2026-04-22T09:36:42","modified_gmt":"2026-04-22T09:36:42","slug":"espray-nasal-de-esketamina","status":"publish","type":"product","link":"https:\/\/trusthillpharmacy.de\/es\/shop\/espray-nasal-de-esketamina\/","title":{"rendered":"Esketamine Aerosol Nasal"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Esketamine Aerosol Nasal<\/a><\/h1>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"lXZu82B\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharmacy.de\/es\/\">Esketamine nasal spray<\/a> is a prescription medication approved by the FDA in 2019 for treating\u00a0<strong>treatment-resistant depression (TRD)<\/strong>\u00a0in adults, and later expanded to include\u00a0<strong>depression with acute suicidal ideation or behavior<\/strong>\u00a0(in combination with an oral antidepressant). It&#8217;s the (S)-enantiomer of ketamine, a dissociative anesthetic, but formulated at a lower dose for psychiatric use. Unlike traditional antidepressants (e.g., SSRIs), it acts rapidly\u2014often within hours\u2014and targets the glutamate system in the brain via NMDA receptor antagonism.<\/p>\n<h4>Los Usos Principales<\/h4>\n<ul>\n<li><strong>Primary indication<\/strong>: TRD (depression not responding to \u22652 prior antidepressants).<\/li>\n<li><strong>Secondary<\/strong>: Major depressive disorder (MDD) with imminent suicide risk.<\/li>\n<li>Administered\u00a0<strong>only in certified healthcare settings<\/strong>\u00a0under the\u00a0<strong>SPRAVATO REMS program<\/strong>\u00a0(Risk Evaluation and Mitigation Strategy) due to risks like sedation, dissociation, and potential abuse.<\/li>\n<\/ul>\n<h4>C\u00f3mo Funciona<\/h4>\n<p class=\"mb-2 last:mb-0\">Esketamine blocks NMDA receptors, increasing glutamate release and activating AMPA receptors. This promotes synaptogenesis (new neural connections) in brain areas like the prefrontal cortex, disrupted in depression. Effects peak in 40 minutes, lasting days to weeks.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Evidencia<\/strong>:<\/p>\n<ul>\n<li><strong>TRANSFORM trials<\/strong>\u00a0(Phase 3): Esketamine + oral antidepressant showed 70% response rate vs. 52% placebo at week 4 (MADRS score reduction \u226550%).<\/li>\n<li><strong>SUSTAIN trials<\/strong>: Sustained benefits over 1 year in maintenance phase.<\/li>\n<li>Meta-analyses (e.g., JAMA Psychiatry 2020) confirm rapid antidepressant effects, superior to placebo but with higher dropout due to side effects.<\/li>\n<\/ul>\n<h4>Dosis y v\u00eda de Administraci\u00f3n<\/h4>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Dosis<\/th>\n<th>Schedule<\/th>\n<th>Notas<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Induction**: 56 mg or 84 mg (2-3 sprays per nostril)<\/td>\n<td>Twice weekly for 4 weeks<\/td>\n<td>Supervised; 2-hour monitoring post-dose.<\/td>\n<\/tr>\n<tr>\n<td>Induction**: Same doses<\/td>\n<td>Weeks 5-8: Once weekly<\/td>\n<td>Taper based on response.<\/td>\n<\/tr>\n<tr>\n<td>Maintenance**: 56-84 mg<\/td>\n<td>Every 1-2 weeks<\/td>\n<td>Long-term as needed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<ul>\n<li>Self-administration\u00a0<strong>prohibited<\/strong>; must be under medical supervision.<\/li>\n<li>Avoid food 2 hours before; no alcohol\/caffeine.<\/li>\n<\/ul>\n<h4>Efectos secundarios<\/h4>\n<p class=\"mb-2 last:mb-0\"><strong>Com\u00fan<\/strong>\u00a0(\u226520% patients):<\/p>\n<ul>\n<li>Dissociation (e.g., feeling detached, 40-75%).<\/li>\n<li>Dizziness\/vertigo.<\/li>\n<li>Nausea, headache.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Seria<\/strong>\u00a0(black box warnings):<\/p>\n<ul>\n<li><strong>Sedation\/abuse potential<\/strong>: Respiratory depression risk; Schedule III controlled substance.<\/li>\n<li><strong>Blood pressure spikes<\/strong>\u00a0(monitor 2 hours post-dose).<\/li>\n<li><strong>Suicidality<\/strong>\u00a0risk in young adults (monitor closely).<\/li>\n<li>Rare: Mania, cognitive impairment.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Evidencia<\/strong>: In trials, 5% discontinued due to dissociation; BP increases &gt;90 mmHg systolic in 10-20%.<\/p>\n<h4>Contraindications and Warnings<\/h4>\n<ul>\n<li><strong>Evitar con<\/strong>: MAOIs (14-day washout), psychostimulants, CNS depressants.<\/li>\n<li><strong>No para<\/strong>: Aneurysms, arteriovenous malformations, recent heart attack\/stroke.<\/li>\n<li>Pregnancy: Category not assigned; limited data\u2014avoid (potential fetal harm).<\/li>\n<li>Driving: No operation of vehicles\/machinery until next day.<\/li>\n<\/ul>\n<h4>Comparisons<\/h4>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Treatment<\/th>\n<th>Inicio<\/th>\n<th>Efficacy (TRD)<\/th>\n<th>Administraci\u00f3n<\/th>\n<th>Cost (US, approx.)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Esketamine<\/td>\n<td>Hours-Days<\/td>\n<td>60-70% response<\/td>\n<td>Clinic, nasal<\/td>\n<td>$600-900\/dose<\/td>\n<\/tr>\n<tr>\n<td>IV Ketamine** (off-label)<\/td>\n<td>Hours<\/td>\n<td>Similar<\/td>\n<td>Clinic, IV<\/td>\n<td>$400-800\/session<\/td>\n<\/tr>\n<tr>\n<td>SSRIs\/SNRIs<\/td>\n<td>4-6 weeks<\/td>\n<td>40-50%<\/td>\n<td>Home, oral<\/td>\n<td>$10-50\/month<\/td>\n<\/tr>\n<tr>\n<td>ECT<\/td>\n<td>Days<\/td>\n<td>70-90%<\/td>\n<td>Clinic, procedure<\/td>\n<td>$2,000+\/session<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<h4>Access and Cost<\/h4>\n<ul>\n<li><strong>A NOSOTROS<\/strong>: ~1,000 certified centers; insurance often covers for TRD (e.g., Medicare Part B).<\/li>\n<li><strong>Global<\/strong>: Approved in EU, Canada, Australia; limited elsewhere.<\/li>\n<li>Generic: None yet (patent until ~2033).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Fuentes<\/strong>: FDA label (Spravato.com), APA guidelines, New England Journal of Medicine reviews (2019-2023), clinicaltrials.gov (NCT02417064, etc.). Always consult a psychiatrist\u2014<strong>not a substitute for medical advice<\/strong>. If you&#8217;re considering it, discuss with a provider experienced in ketamine therapies.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex items-center justify-end gap-1 transition-opacity duration-100 opacity-0 group-hover:opacity-100 group-focus-within:opacity-100 md:absolute md:-right-10 md:-top-2\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"relative mx-auto max-w-2xl px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative mb-4 flex items-start md:-ml-12\">\n<div class=\"sm:ml-4 flex-1 space-y-2 overflow-hidden pr-1\">\n<div class=\"flex w-full items-center justify-between\">\n<div class=\"flex items-center space-x-1\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Esketamine Nasal Spray Esketamine nasal spray is a prescription medication approved by the FDA in 2019 for treating\u00a0treatment-resistant depression (TRD)\u00a0in adults, and later expanded to include\u00a0depression with acute suicidal ideation or behavior\u00a0(in combination with an oral antidepressant). It&#8217;s the (S)-enantiomer of ketamine, a dissociative anesthetic, but formulated at a lower dose for psychiatric use. Unlike &hellip; <a href=\"https:\/\/trusthillpharmacy.de\/es\/shop\/espray-nasal-de-esketamina\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Esketamine Aerosol Nasal<\/span><\/a><\/p>","protected":false},"featured_media":7954,"template":"","meta":[],"product_brand":[],"product_cat":[15],"product_tag":[227],"class_list":{"0":"post-7950","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-uncategorized","7":"product_tag-esketamine-nasal-spray","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Esketamine Nasal Spray - Trusthill Pharmacy<\/title>\n<meta name=\"description\" content=\"Esketamine nasal spray is a prescription medication approved for treating\u00a0treatment-resistant depression\u00a0in adults, &amp; later expanded to include\u00a0depression.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trusthillpharmacy.de\/es\/shop\/espray-nasal-de-esketamina\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Esketamine Nasal Spray\" \/>\n<meta property=\"og:description\" content=\"Esketamine nasal spray is a prescription medication approved for treating\u00a0treatment-resistant depression\u00a0in adults, &amp; later expanded to include\u00a0depression.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/trusthillpharmacy.de\/es\/shop\/espray-nasal-de-esketamina\/\" \/>\n<meta property=\"og:site_name\" content=\"Trusthill Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-22T09:36:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/trusthillpharmacy.de\/wp-content\/uploads\/2026\/04\/photo_5132142751293050303_y.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/trusthillpharmacy.de\\\/shop\\\/esketamine-nasal-spray\\\/\",\"url\":\"https:\\\/\\\/trusthillpharmacy.de\\\/shop\\\/esketamine-nasal-spray\\\/\",\"name\":\"Esketamine Nasal Spray - 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