{"id":7736,"date":"2026-04-09T10:15:59","date_gmt":"2026-04-09T10:15:59","guid":{"rendered":"https:\/\/trusthillpharmacy.de\/?post_type=product&#038;p=7736"},"modified":"2026-04-14T16:02:12","modified_gmt":"2026-04-14T16:02:12","slug":"co-codamol-15-500mg","status":"publish","type":"product","link":"https:\/\/trusthillpharmacy.de\/nl\/shop\/co-codamol-15-500mg\/","title":{"rendered":"Co-Codamol 15\/500mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Co-Codamol 15\/500mg<\/a><\/h1>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>Wat het is:<\/strong><br \/>\n<a href=\"https:\/\/trusthillpharmacy.de\/nl\/\">Co-Codamol<\/a> 15\/500mg is een gecombineerde pijnstiller die het volgende bevat:<\/p>\n<ul>\n<li><strong>Codeine phosphate<\/strong>: 15 mg (een opio\u00efde pijnstiller die werkt door zich te binden aan opio\u00efde receptoren in de hersenen om de pijnperceptie te verminderen).<\/li>\n<li><strong>Paracetamol (acetaminophen)<\/strong>: 500 mg (een niet-opio\u00efde pijnstiller en koortsverlagend middel dat de prostaglandinesynthese in het centrale zenuwstelsel remt).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\">Dit is een formulering met een lagere sterkte (Co-Codamol 15\/500 mg) in vergelijking met hogere doseringen zoals 30\/500 of 8\/500. Het is in sommige landen (bijvoorbeeld het VK) zonder recept verkrijgbaar in beperkte verpakkingen, maar voor sterkere varianten is een recept nodig.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Veelvoorkomende toepassingen:<\/strong><\/p>\n<ul>\n<li>Verlichting van lichte tot matige pijn (bijv. hoofdpijn, tandpijn, spierpijn, menstruatiepijn, spierpijn na een blessure).<\/li>\n<li>Uitsluitend voor kortdurend gebruik (doorgaans maximaal 3 dagen voor producten die code\u00efne bevatten om afhankelijkheid te voorkomen).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Bewijs en effectiviteit:<\/strong><\/p>\n<ul>\n<li>Ondersteund door NHS-richtlijnen en studies in\u00a0<em>De Lancet<\/em>\u00a0(Bijvoorbeeld, combinaties van code\u00efne en paracetamol bieden een betere pijnverlichting dan paracetamol alleen bij acute pijn, met een NNT van ongeveer 4 voor 50% pijnverlichting \u2013 McQuay et al., meta-analyses uit de jaren 90).<\/li>\n<li>Co-Codamol 15\/500mg wordt via het CYP2D6-enzym omgezet in morfine; ongeveer 10% van de mensen heeft een verminderde werking en ondervindt daardoor minder voordeel (de FDA heeft waarschuwingen in de bijsluiter afgegeven over deze variabiliteit).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Dosering (volwassenen):<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Leeftijd Groep<\/th>\n<th>Maximale dagelijkse dosis<\/th>\n<th>Opmerkingen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Volwassenen (16+)<\/td>\n<td>8 tabletten (120 mg code\u00efne \/ 4 g paracetamol)<\/td>\n<td>1-2 tabletten elke 4-6 uur; niet meer innemen.<\/td>\n<\/tr>\n<tr>\n<td>Kinderen (12-15)<\/td>\n<td>1 tablet elke 6 uur (maximaal 4 per dag)<\/td>\n<td>Niet geschikt voor kinderen onder de 12 jaar.<\/td>\n<\/tr>\n<tr>\n<td>Ouderen\/Leverproblemen<\/td>\n<td>Dosis verlagen<\/td>\n<td>Raadpleeg een arts.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><strong>Bijwerkingen:<\/strong><\/p>\n<ul>\n<li><strong>Common<\/strong>: Slaperigheid, duizeligheid, constipatie, misselijkheid (gerelateerd aan code\u00efne); incidentie van ongeveer 20-30% volgens klinische onderzoeken.<\/li>\n<li><strong>Ernstig<\/strong>Ademhalingsdepressie (zelden bij lage doses), risico op verslaving (code\u00efne is een gereguleerde stof), paracetamoloverdosis \u2192 leverfalen (toxische metaboliet NAPQI overbelast de glutathionvoorraden; risico van &gt;4 g\/dag volgens MHRA).<\/li>\n<li><strong>Allergisch<\/strong>Uitslag, zwelling.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Waarschuwingen en interacties:<\/strong><\/p>\n<ul>\n<li><strong>Niet combineren met<\/strong>Alcohol, andere opio\u00efden, kalmeringsmiddelen (verhoogt het risico op een overdosis \u2013 zie de richtlijnen van de CDC voor opio\u00efden).<\/li>\n<li><strong>Vermijden indien<\/strong>Contra-indicaties: zwangerschap\/borstvoeding (code\u00efne komt in de moedermelk terecht), astma, lever-\/nieraandoeningen of een voorgeschiedenis van verslaving.<\/li>\n<li><strong>Tekenen van een overdosis<\/strong>Braken, vernauwde pupillen, coma \u2013 roep onmiddellijk medische hulp in (naloxon bij code\u00efne; N-acetylcyste\u00efne bij paracetamol).<\/li>\n<li>De Britse MHRA adviseert het gebruik van code\u00efne af te raden voor kinderen onder de 12 jaar vanwege het risico op slaapapneu (besluit uit 2013 gebaseerd op farmacovigilantiegegevens).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Beschikbaarheid:<\/strong><\/p>\n<ul>\n<li>VK: Zonder recept verkrijgbaar bij de apotheek (maximaal 16 tabletten per verpakking); recept voor grotere hoeveelheden.<\/li>\n<li>VS: Het equivalent is Tylenol #2 (vergelijkbare sterkte); code\u00efne is alleen op recept verkrijgbaar.<\/li>\n<li>Controleer altijd de lokale regelgeving.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\">Dit is algemene informatie afkomstig van bronnen zoals BNF, NHS, EMA en FDA-etiketten.\u00a0<strong>geen medisch advies<\/strong>Raadpleeg een arts of apotheker voor persoonlijk gebruik van Co-Codamol 15\/500mg, vooral als u gezondheidsproblemen heeft of andere medicijnen gebruikt. Als u pijn ervaart, beschrijf dan uw symptomen voor advies op maat.<\/p>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Co-Codamol 15\/500mg What it is: Co-Codamol 15\/500mg is a combination painkiller containing: Codeine phosphate: 15 mg (an opioid analgesic that works by binding to opioid receptors in the brain to reduce pain perception). Paracetamol (acetaminophen): 500 mg (a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system). This is &hellip; <a href=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/co-codamol-15-500mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Co-Codamol 15\/500mg<\/span><\/a><\/p>","protected":false},"featured_media":7749,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[211],"class_list":["post-7736","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-co-codamol-15-500mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Co-Codamol 15\/500mg - Trusthill Pharmacy<\/title>\n<meta name=\"description\" content=\"Co-Codamol 15\/500mg is a a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/co-codamol-15-500mg\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Co-Codamol 15\/500mg\" \/>\n<meta property=\"og:description\" content=\"Co-Codamol 15\/500mg is a a non-opioid pain reliever and fever reducer that inhibits prostaglandin synthesis in the central nervous system\" \/>\n<meta property=\"og:url\" content=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/co-codamol-15-500mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Trusthill Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-14T16:02:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/trusthillpharmacy.de\/wp-content\/uploads\/2026\/04\/photo_5096273778597104775_x.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Geschatte leestijd\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/trusthillpharmacy.de\\\/shop\\\/co-codamol-15-500mg\\\/\",\"url\":\"https:\\\/\\\/trusthillpharmacy.de\\\/shop\\\/co-codamol-15-500mg\\\/\",\"name\":\"Co-Codamol 15\\\/500mg - 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