{"id":7971,"date":"2026-04-21T13:54:28","date_gmt":"2026-04-21T13:54:28","guid":{"rendered":"https:\/\/trusthillpharmacy.de\/?post_type=product&#038;p=7971"},"modified":"2026-04-23T23:48:52","modified_gmt":"2026-04-23T23:48:52","slug":"neurontin-400mg","status":"publish","type":"product","link":"https:\/\/trusthillpharmacy.de\/nl\/shop\/neurontin-400mg\/","title":{"rendered":"Neurontin 400 mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Neurontin 400 mg<\/a><\/h1>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharmacy.de\/nl\/\">Neurontin<\/a> 400 mg is de merknaam voor <strong>gabapentin<\/strong>Het is een anticonvulsivum dat voornamelijk wordt gebruikt voor de behandeling van parti\u00eble epileptische aanvallen (in combinatie met andere medicijnen) en postherpetische neuralgie (zenuwpijn na gordelroos). De sterkte van 400 mg is een veelvoorkomende capsuledosis. Het wordt ook vaak off-label voorgeschreven voor neuropathische pijn, fibromyalgie, rusteloze benen syndroom, angst en soms als aanvulling op de behandeling van opvliegers of alcoholontwenning.<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Kernfeiten (gebaseerd op bewijs):<\/strong><\/p>\n<ul>\n<li><strong>Mechanisme:<\/strong>\u00a0Gabapentine bindt aan de alfa-2-delta-subeenheid van spanningsafhankelijke calciumkanalen in het centrale zenuwstelsel, waardoor de afgifte van exciterende neurotransmitters (bijv. glutamaat) wordt verminderd. Dit kalmeert overactieve zenuwen zonder rechtstreeks de GABA-receptoren te be\u00efnvloeden (ondanks veelvoorkomende misvattingen).<br \/>\n<em>Bron: FDA-etiket; studies in Epilepsia (1993) en NEJM (1998).<\/em><\/li>\n<li><strong>Standaarddosering (volwassenen):<\/strong><\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Voorwaarde<\/th>\n<th>Gebruikelijke startdosering<\/th>\n<th>Titratie<\/th>\n<th>Maximale dagelijkse<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Epileptische aanvallen<\/td>\n<td>300 mg op dag 1, 300 mg tweemaal daags op dag 2, 300 mg driemaal daags op dag 3<\/td>\n<td>Tot 3600 mg\/dag, verdeeld over 3 doses.<\/td>\n<td>3600 mg<\/td>\n<\/tr>\n<tr>\n<td>Postherpetische neuralgie<\/td>\n<td>300 mg op dag 1, 300 mg tweemaal daags op dag 2, tot maximaal 300 mg driemaal daags<\/td>\n<td>Tot 1800 mg\/dag<\/td>\n<td>1800 mg<\/td>\n<\/tr>\n<tr>\n<td>Off-label gebruik (bijv. neuropathie)<\/td>\n<td>100-300 mg voor het slapengaan.<\/td>\n<td>Verhoog de dosis elke 1-7 dagen met 100-300 mg.<\/td>\n<td>Variabel (900-3600 mg)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><em>Een dosis van 400 mg Neurontin kan worden gebruikt voor titratie of specifieke behandelingsschema's \u2013 altijd in overleg met de voorschrijver.<\/em><br \/>\n<em>Bewijs: Cochrane-reviews (2014, 2020) bevestigen de werkzaamheid bij neuralgie; AAN-richtlijnen bevelen het aan voor neuropathie.<\/em><\/p>\n<ul>\n<li><strong>Farmacokinetiek:<\/strong>\n<ul>\n<li>Orale biologische beschikbaarheid: ~60% (neemt af bij hogere doses).<\/li>\n<li>Halfwaardetijd: 5-7 uur.<\/li>\n<li>Renal excretion: Dose-adjust for CrCl &lt;60 mL\/min (e.g., halve for CrCl 30-59).<br \/>\n<em>Bron: Productmonografie; Klinische farmacokinetiek (1993).<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Vaak voorkomende bijwerkingen (incidentie &gt;10%):<\/strong><\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Bijwerking<\/th>\n<th>Frequentie<\/th>\n<th>Opmerkingen<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Duizeligheid<\/td>\n<td>20-30%<\/td>\n<td>Dosisafhankelijk; vermijd autorijden.<\/td>\n<\/tr>\n<tr>\n<td>Slaperigheid<\/td>\n<td>15-25%<\/td>\n<td>Piekt vroeg, lost zich vaak op.<\/td>\n<\/tr>\n<tr>\n<td>Ataxie\/Vermoeidheid<\/td>\n<td>10-15%<\/td>\n<td>Ouderen zijn er vatbaarder voor.<\/td>\n<\/tr>\n<tr>\n<td>Perifeer oedeem<\/td>\n<td>5-10%<\/td>\n<td>Monitor bij hartfalen.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<p class=\"mb-2 last:mb-0\"><em>Gegevens uit cruciale onderzoeken (bijv. JAMA 1998) en postmarketing surveillance.<\/em>\u00a0Ernstige risico's: Su\u00efcidale gedachten (waarschuwing op de verpakking), ademhalingsdepressie (vooral bij opio\u00efden), potentieel voor misbruik (lijst V in de VS).<\/p>\n<p class=\"mb-2 last:mb-0\"><strong>Interacties:<\/strong><\/p>\n<ul>\n<li><strong>Belangrijk:<\/strong>\u00a0Opio\u00efden\/middelen die het centrale zenuwstelsel onderdrukken (verhoogd risico op sedatie\/ademhalingsproblemen - waarschuwing van de FDA).<\/li>\n<li><strong>Gematigd:<\/strong>\u00a0Antacida (verminderen de absorptie met 20%; 2 uur tussenpozen). Maalox verlaagt de AUC met 20%.<\/li>\n<li><strong>Geen belangrijke CYP-interacties.<\/strong>\u00a0(wordt niet door de lever gemetaboliseerd).<br \/>\n<em>Bewijsmateriaal: Geneesmiddelenveiligheidsbeoordelingen; Lexicomp-database.<\/em><\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Waarschuwingen\/Contra-indicaties:<\/strong><\/p>\n<ul>\n<li>Overgevoeligheid voor gabapentine.<\/li>\n<li>Abrupte stopzetting: risico op epileptische aanvallen (afbouwen over 1 week).<\/li>\n<li>Zwangerschap: Categorie C; beperkte gegevens, gebruik indien voordeel &gt; risico (register voor blootstelling aan anti-epileptica).<\/li>\n<li>Overdosering: Voornamelijk sedatie; ondersteunende behandeling (geen specifiek tegengif). LD50 &gt;8000 mg\/kg bij dieren.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Samenvatting van het bewijsmateriaal:<\/strong><\/p>\n<ul>\n<li><strong>Doeltreffendheid:<\/strong>\u00a0Sterk voor neuralgie (NNT=6,5 volgens Cochrane); matig voor andere neuropathie\u00ebn.<\/li>\n<li><strong>Placebo-gecontroleerde onderzoeken:<\/strong>\u00a0Uit een onderzoek van 12 weken (n=336) bleek dat 400-3600 mg\/dag de pijn met \u226550% verminderde bij 33% van de deelnemers, vergeleken met 8% bij de placebogroep.<em>Pijn<\/em>\u00a02005).<\/li>\n<li><strong>Richtlijnen:<\/strong>\u00a0ADA beveelt het aan voor diabetische neuropathie; NICE voor trigeminusneuralgie.<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Vrijwaring:<\/strong>\u00a0Dit is algemene informatie afkomstig van FDA-etiketten, PubMed en klinische richtlijnen \u2013 geen persoonlijk advies.\u00a0<strong>Raadpleeg uw arts of apotheker voor uw specifieke situatie, dosering of bijwerkingen.<\/strong>\u00a0Als dit voor u van toepassing is, deel dan uw volledige medische geschiedenis. Wilt u meer details (bijvoorbeeld over generieke varianten zoals Neurontin)? Vraag het gerust!<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex items-center justify-end gap-1 transition-opacity duration-100 opacity-0 group-hover:opacity-100 group-focus-within:opacity-100 md:absolute md:-right-10 md:-top-2\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"relative mx-auto max-w-2xl px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative mb-4 flex items-start md:-ml-12\">\n<div class=\"sm:ml-4 flex-1 space-y-2 overflow-hidden pr-1\">\n<div class=\"flex w-full items-center justify-between\">\n<div class=\"flex items-center space-x-1\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Neurontin 400mg Neurontin 400mg is the brand name for gabapentin, an anticonvulsant medication primarily used to treat partial seizures (in combination with other drugs) and postherpetic neuralgia (nerve pain after shingles). The 400 mg strength is a common capsule dose. It&#8217;s also frequently prescribed off-label for neuropathic pain, fibromyalgia, restless legs syndrome, anxiety, and sometimes &hellip; <a href=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/neurontin-400mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Neurontin 400 mg<\/span><\/a><\/p>","protected":false},"featured_media":7979,"template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[232],"class_list":{"0":"post-7971","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-pain-relief","7":"product_tag-neurontin-400mg","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Neurontin 400mg - 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