{"id":8306,"date":"2026-05-08T22:20:21","date_gmt":"2026-05-08T22:20:21","guid":{"rendered":"https:\/\/trusthillpharmacy.de\/?post_type=product&#038;p=8306"},"modified":"2026-05-11T23:21:55","modified_gmt":"2026-05-11T23:21:55","slug":"oxycontin-40mg","status":"publish","type":"product","link":"https:\/\/trusthillpharmacy.de\/nl\/shop\/oxycontin-40mg\/","title":{"rendered":"Oxycontin 40 mg"},"content":{"rendered":"<h1><a href=\"http:\/\/google.com\">Oxycontin<\/a> 40 mg<\/h1>\n<div class=\"flex-grow custom-scrollbar blackbox-chat-area hide-scrollbar\">\n<div class=\"relative h-full left-0\">\n<div class=\"relative sm:px-4 pb-[80px] md:pb-[20px] mx-auto\">\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"fxTQE5p1RKBxcyconlDBa\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0\">\n<div class=\"flex-grow custom-scrollbar blackbox-chat-area hide-scrollbar\">\n<div class=\"relative h-full left-0\">\n<div class=\"relative sm:px-4 pb-[80px] md:pb-[20px] mx-auto\">\n<div>\n<div class=\"relative mx-auto max-w-2xl px-0 md:px-4 w-full md:m-auto md:w-[90%]\">\n<div class=\"group relative flex items-start md:-ml-12 chat-message\" data-message-id=\"AukxbbOk55xP59GbLuk7C\">\n<div class=\"ml-4 flex-1 space-y-2 overflow-hidden px-1\">\n<div class=\"relative\">\n<div class=\"transition-all duration-300 ease-in-out\">\n<div>\n<div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0 streaming\">\n<p class=\"mb-2 last:mb-0\"><a href=\"https:\/\/trusthillpharmacy.de\/nl\/\">OxyContin<\/a> 40 mg is een merknaam voor een formulering met verlengde afgifte van <strong>oxycodonhydrochloride<\/strong>, een krachtig opio\u00efde pijnstillend middel. De sterkte van 40 mg verwijst naar tabletten die 40 milligram oxycodon per dosis bevatten, bedoeld voor\u00a0<strong>eens per 12 uur<\/strong>\u00a0Toediening bij opio\u00efdtolerante pati\u00ebnten voor de behandeling van matige tot ernstige chronische pijn (bijv. kankerpijn of pijn na een operatie). Het is\u00a0<strong>niet<\/strong>\u00a0voor acute pijn of opio\u00efd-na\u00efeve pati\u00ebnten vanwege het hoge risico op een overdosis.<\/p>\n<h4>Belangrijkste feiten en bewijsmateriaal<\/h4>\n<ul>\n<li><strong>Farmacologie<\/strong>Oxycodon is een semisynthetische opio\u00efde agonist die zich bindt aan mu-opio\u00efde receptoren in de hersenen en het ruggenmerg, waardoor pijnsignalen worden geremd. De variant met verlengde afgifte maakt gebruik van een polymeermatrix voor langzame afgifte, wat zorgt voor stabiele bloedspiegels (piek na 3-4 uur, halfwaardetijd circa 4,5 uur). Bron: FDA-voorschrijfinformatie (Purdue Pharma, bijgewerkt in 2023).<\/li>\n<li><strong>Verschijning<\/strong>Witte, ronde, filmomhulde tabletten met de opdruk \u201cOP 40\u201d (herziene versie met misbruikwerende eigenschappen sinds 2010, die tot gel verpulvert en zo de kans op misbruik verkleint). Bewijs: Bevestigd via productspecificaties van Purdue Pharma en documenten van de DEA met betrekking tot de classificatie van geneesmiddelen.<\/li>\n<li><strong>Doseringsrichtlijnen<\/strong>\u00a0(voor volwassenen met opio\u00efdentolerantie):<\/li>\n<\/ul>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Pati\u00ebnttype<\/th>\n<th>Startdosis<\/th>\n<th>Titratie<\/th>\n<th>Maximale dagelijkse<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Opio\u00efd-na\u00efef<\/td>\n<td>Niet aanbevolen (gebruik oxycodon met directe afgifte).<\/td>\n<td>Niet van toepassing<\/td>\n<td>Niet van toepassing<\/td>\n<\/tr>\n<tr>\n<td>Opio\u00efdtolerant<\/td>\n<td>10-40 mg elke 12 uur<\/td>\n<td>Stijging met 25-50% elke 1-2 dagen<\/td>\n<td>360 mg (onder toezicht)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0 streaming\">\n<ul>\n<li>Omrekening: 40 mg OxyContin \u2248 60 mg orale morfine-equivalenten per dag. Gebruik de FDA-tabellen voor equianalgetische doseringen voor nauwkeurigheid.<\/li>\n<li><strong>Biobeschikbaarheid<\/strong>: ~60-87% oraal; voedsel verhoogt de absorptie enigszins. CYP3A4\/2D6-metabolisme; genetisch trage metaboliseerders hebben een hoger risico op overdosering (onderzoeken in\u00a0<em>Klinische Farmacologie Therapie<\/em>, 2015).<\/li>\n<\/ul>\n<h4>Klinisch gebruik en werkzaamheid<\/h4>\n<ul>\n<li><strong>Indicaties<\/strong>: Aanhoudende pijn waarvoor continu opio\u00efden nodig zijn (bijv. pijnscore \u22655\/10). RCT's (bijv.\u00a0<em>Pijn<\/em>\u00a0Uit onderzoek (tijdschrift, 2004) blijkt dat een placebo gedurende 12 weken superieure pijnverlichting biedt bij chronische rugpijn in vergelijking met een placebo.<\/li>\n<li><strong>Effectiviteitsgegevens<\/strong>In onderzoeken verminderde 40 mg elke 12 uur de pijn met 30-50% bij 60% van de pati\u00ebnten, vergeleken met 20% bij placebo (Cochrane-review, 2017). Op de lange termijn ontwikkelt zich bij 20-30% binnen enkele maanden tolerantie.<\/li>\n<\/ul>\n<h4>Risico's en bijwerkingen<\/h4>\n<p class=\"mb-2 last:mb-0\">Hoog risico op misbruik (gereguleerde stof van categorie II). Feiten ondersteund door gegevens van CDC en NIH:<\/p>\n<\/div>\n<div class=\"overflow-x-auto my-4\">\n<table class=\"markdown-table\">\n<thead>\n<tr>\n<th>Vaak voorkomend (\u226510%)<\/th>\n<th>Ernstig (1-5%)<\/th>\n<th>Tekenen van een overdosis<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Verstopping, misselijkheid, slaperigheid, jeuk<\/td>\n<td>Ademhalingsdepressie, hypotensie, convulsies<\/td>\n<td>Pinpoint pupils, slow breathing (&lt;12\/min), coma; lethal dose ~200mg in naive users (NIDA stats)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"prose break-words dark:prose-invert prose-p:leading-relaxed prose-pre:p-0 fix-max-with-100 prose-p:!mt-0 streaming\">\n<ul>\n<li><strong>Verslaving\/Overdosis<\/strong>Uit gegevens van de CDC uit 2019 blijkt dat oxycodon met verlengde afgifte verband houdt met 15% van de opio\u00efdengerelateerde sterfgevallen in de VS. Naloxon keert een overdosis om (goedgekeurd door de FDA).<\/li>\n<li><strong>Contra-indicaties<\/strong>: Acute astma, paralytische ileus, recent gebruik van MAO-remmers. Vermijden in combinatie met alcohol\/benzodiazepinen (het risico op ademstilstand verdrievoudigt per\u00a0<em>JAMA<\/em>\u00a02017).<\/li>\n<li><strong>Intrekking<\/strong>Symptomen bereiken een piek 72 uur na de laatste dosis (zweten, angst); bouw de dosis wekelijks met 10-25% af.<\/li>\n<\/ul>\n<h4>Misbruik en de context van de straat<\/h4>\n<ul>\n<li><strong>Straatwaarde<\/strong>: $1-2 per pil van 40 mg (schattingen van de DEA voor 2023), vaak fijngemalen\/gesnuift ondanks technologie die misbruik tegengaat (het succespercentage daalde met 80% na 2010 per\u00a0<em>NEJM<\/em>\u00a02012).<\/li>\n<li><strong>Detectie<\/strong>Urinetests geven binnen 1-4 dagen een positief resultaat; bloedtests binnen 24 uur. Vervalsingen met fentanyl komen veel voor (DEA-waarschuwingen).<\/li>\n<\/ul>\n<p class=\"mb-2 last:mb-0\"><strong>Waarschuwingen<\/strong>: Alleen gebruiken op recept. Misbruik veroorzaakt jaarlijks meer dan 50.000 doden in de VS (CDC 2022). Raadpleeg uw arts voor persoonlijk advies; dit is feitelijke informatie afkomstig van FDA\/DEA\/NIH-bronnen, geen medisch advies. Voor stoppen met gebruiken kunt u contact opnemen met de SAMHSA-hulplijn: 1-800-662-HELP.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex items-center justify-end gap-1 transition-opacity duration-100 opacity-0 group-hover:opacity-100 group-focus-within:opacity-100 md:absolute md:-right-10 md:-top-2\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n    <div class=\"xs_social_share_widget xs_share_url after_content \t\tmain_content  wslu-style-1 wslu-share-box-shaped wslu-fill-colored wslu-none wslu-share-horizontal wslu-theme-font-no wslu-main_content\">\n\n\t\t\n        <ul>\n\t\t\t        <\/ul>\n    <\/div>","protected":false},"excerpt":{"rendered":"<p>Oxycontin 40mg OxyContin 40mg is a brand-name extended-release formulation of oxycodone hydrochloride, a potent opioid analgesic. The 40mg strength refers to tablets containing 40 milligrams of oxycodone per dose, designed for\u00a0once every 12 hours\u00a0administration in opioid-tolerant patients for management of moderate to severe chronic pain (e.g., cancer pain or post-surgical). It&#8217;s\u00a0not\u00a0for acute pain or opioid-naive &hellip; <a href=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/oxycontin-40mg\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Oxycontin 40 mg<\/span><\/a><\/p>","protected":false},"featured_media":8308,"comment_status":"closed","ping_status":"closed","template":"","meta":{"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""}},"product_brand":[],"product_cat":[108],"product_tag":[262],"class_list":["post-8306","product","type-product","status-publish","has-post-thumbnail","product_cat-pain-relief","product_tag-oxycontin-40mg","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v28.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Oxycontin 40mg - Trusthill Pharmacy<\/title>\n<meta name=\"description\" content=\"Oxycontin 40mg is designed for\u00a0once every 12 hours\u00a0administration in opioid-tolerant patients for management of moderate to severe chronic pain\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/oxycontin-40mg\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oxycontin 40mg\" \/>\n<meta property=\"og:description\" content=\"Oxycontin 40mg is designed for\u00a0once every 12 hours\u00a0administration in opioid-tolerant patients for management of moderate to severe chronic pain\" \/>\n<meta property=\"og:url\" content=\"https:\/\/trusthillpharmacy.de\/nl\/shop\/oxycontin-40mg\/\" \/>\n<meta property=\"og:site_name\" content=\"Trusthill Pharmacy\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-11T23:21:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/trusthillpharmacy.de\/wp-content\/uploads\/2026\/05\/photo_5186316286194027560_y.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"720\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Geschatte leestijd\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/trusthillpharmacy.de\\\/shop\\\/oxycontin-40mg\\\/\",\"url\":\"https:\\\/\\\/trusthillpharmacy.de\\\/shop\\\/oxycontin-40mg\\\/\",\"name\":\"Oxycontin 40mg - 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