Xenical 120mg is a prescription medication containing orlistat 120mg per capsule, primarily used for weight management in adults who are obese (BMI ≥30 kg/m²) or overweight (BMI ≥27 kg/m²) with related health risks like hypertension, diabetes, or high cholesterol. It’s not a “magic pill” but works alongside a reduced-calorie diet and exercise.

Wie Es Funktioniert

• Mechanismus: Orlistat is a lipase inhibitor. It binds to enzymes in the gut (gastric and pancreatic lipases), preventing the breakdown and absorption of about 25-30% of dietary fats. Unabsorbed fats are excreted in stool.
• Hinweise: Clinical trials (e.g., 4-year XENDOS study, n=3304) showed ~10% average weight loss over 1 year vs. placebo, with sustained benefits when combined with lifestyle changes. FDA-approved since 1999; also EMA-approved.

Dosierung Und Verwaltung

Nebenwirkungen

Mostly gastrointestinal (GI) due to fat malabsorption—occur in ~20-30% of users, dose-dependent on dietary fat. | Common (≥10%) | Oily spotting, flatulence with discharge, fecal urgency, fatty/oily stool, liquid stool, fecal incontinence, increased defecation. | | Less Common (1-10%) | Abdominal pain, nausea, headache, menstrual changes. | | Rare/Serious (<1%) | Liver injury (monitor LFTs), kidney stones (oxalate-related), severe allergic reactions. Hypothyroidism risk if iodine-deficient. |

Multivitamin required: Take 2+ hours before/after Xenical (fat-soluble vitamins A, D, E, K depleted).

Gegenanzeigen & Warnhinweise

• Nicht verwenden, wenn: Chronic malabsorption syndrome, cholestasis, pregnancy/breastfeeding, known hypersensitivity.
• Caution: IBD, renal impairment (monitor oxalate), diabetes (adjust meds as weight loss affects glucose).
• Arzneimittelwechselwirkungen: Reduces absorption of cyclosporine, amiodarone, warfarin, antiepileptics—space doses. Avoid high-fat supplements.
• Überdosis: No specific antidote; symptomatic treatment (e.g., anti-diarrheals).

Effectiveness Data

Verfügbarkeit und Kosten

• Prescription-only in most countries (e.g., US, EU, Australia). OTC version (Alli 60mg) exists for milder use.
• Generic orlistat available, cheaper (~5+).

Wichtig: This is general info from sources like FDA label, EMA SPC, and studies (e.g., PubMed). Keine medizinische Beratung—consult a doctor for personalized use, as it requires BMI assessment and monitoring. Side effects can be socially disruptive; adherence is key (~50% dropout rate in trials). If you have specific questions (e.g., interactions), provide more details!