Dapoxetine (brand names: Priligy, others) is a selective serotonin reuptake inhibitor (SSRI) specifically developed and approved for treating premature ejaculation (PE) in adult men aged 18-64. The standard dose is 60 mg, taken as needed 1-3 hours before anticipated sexual activity. It’s niet for erectile dysfunction (ED) or daily use like other SSRIs (e.g., for depression).

Belangrijkste feiten en bewijsmateriaal

• Mechanisme: It works by increasing serotonin levels in the brain, delaying ejaculation by modulating the ejaculatory reflex. Clinical trials (e.g., phase III studies published in De Lancet 2006 and Journal of Sexual Medicine 2009) showed it extends intravaginal ejaculatory latency time (IELT) by 2.5-3x compared to placebo (from ~1 min to ~3-4 min).
• Approval: Approved by EMA (Europe, 2009), FDA (not in US but available via import), and in many countries like India, Australia. Not for women or children.
• Dosering:

Efficacy Data

• Meta-analyses (e.g., Urology 2019, reviewing 6 RCTs with >6,000 men): 60mg improves PE in 70-80% of men vs. 30-40% placebo. Patient-reported satisfaction increases ~3x.
• Best for lifelong or acquired PE with IELT <2 min.

Side Effects (Common: 10-20% incidence)

• Contra-indicaties: Heart disease, liver/kidney failure, bipolar disorder, concurrent MAOIs/SSRIs/thioridazine, moderate-severe alcohol use. Avoid if PE is due to ED or prostatitis.
• Interacties: Potentiates with CYP3A4 inhibitors (ketoconazole, ritonavir), alcohol (↑dizziness), PDE5 inhibitors (e.g., sildenafil—use caution, monitor BP).

Usage Tips (Supported by Guidelines)

• Swallow whole with water; no food restriction but avoid grapefruit.
• Not for daily use—half-life ~1.5 hrs, cleared quickly.
• Lifestyle: Combine with behavioral therapy (e.g., stop-start technique) for better results (BJU International 2014).
• Overdosis: >240mg risky; seek ER for nausea/vomiting/seizures.

Belangrijk: This is general info from sources like EMA/FDA labels, PubMed reviews (e.g., PMID 19453821). I’m not a doctor—consult a physician for personalized advice, prescription, and screening (e.g., for heart risks). Self-medication can be dangerous. Available OTC in some places but requires medical oversight. If buying online, verify legitimacy to avoid counterfeits.